Prof. Kharkar is a big proponent of collaboration as seen from his collaborative research efforts in India and abroad. Prof. Kharkar is actively linked to researchers abroad on various fronts. He has collaborators in USA, Italy, Germany, South Africa, Turkey, South-East Asia and Mauritius.
For SARS-CoV-2 project, Prof. Kharkar established active collaboration with National Institute of Allergy and Infectious Diseases (NIAID) and University of Pennsylvania, PA, USA. For neuroinflammatory agents, he collaborated with Prof. Mahajan at University of Buffalo, NY, USA. The main emphasis is to demonstrate the potential of NCEs based on Natural Products for post-COVID complications including those of neurological origin. The studies have just begun at both the collaborator’s laboratories.
For IMPDH Project, Prof. Kharkar actively collaborated with Dr. Vinayak Singh, University of Cape Town (South Africa) for compound screening in cell-based assay. This collaboration was further extended to Università del Piemonte Orientale, Italy for target screening (10.1016/j.bmcl.2018. 04.045). In addition, the work on IMPDH inhibitors was continued in collaboration with Nycomed Pharma, Konstanz, Germany, which yielded two highly-cited publications (10.3109/14756366.2013. 793184; 10.1007/s10822-012-9615-5).
The dual transporter protein inhibitor project with leading researcher from University of Bonn, Bonn, Germany, yielded moderately potent, dual ABCB1 and ABCG2 inhibitors (DOI: 10.1016/-j.ejmech.2018.12.019). Another interesting collaboration with Department of Food Science and Nutrition, College of Food and Agriculture, King Saud University, Riyadh, Kingdom of Saudi Arabia and In Vitro ADMET Laboratories LLC, Columbia, MD, USA, resulted in a highly-cited publication (10.1007/s10495-015-1159-4).
For yet another anticancer project, the applicant collaborated with University of Mauritius, Mauritius (DOI: 10.2174/1573407214666180829125309). Extension of this collaboration resulted in yet another multinational collaboration for the discovery of favipiravir derivatives as anti-Ebola agents (DOI: 10.1515/psr-2017-0198). Another collaboration with the same group led to an interesting publication featuring computational repurposing of approved drugs for anti-Ebola indication (10.1039/C6RA01704E).
Previously, Prof. Kharkar collaborated with Dr. Claudiu Supuran from Università degli Studi di Firenze, Italy, a pioneering researcher in the field of Carbonic anhydrase (CA) for compound screening. The collaboration resulted in two highly-cited publications (10.1021/ml500140t; 10.1021/ml500140t).
In addition, collaboration with the Post-doc Mentor, Dr. Aloke Dutta, from Wayne State University, Detroit, MI, USA, resulted in an interesting publication, four years after completion of post-doctoral studies 10.1016/j.bmc.2013.03.059).
Overall, Prof. Kharkar has collaborated with Indian and International researchers abroad to investigate complex problems and contribute to the advancement of therapeutic area relevant to Indian population.
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